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Diazepam is N-demethylated by CYP3A4 and 2C19 on the active metabolite N-desmethyldiazepam, and it is hydroxylated by CYP3A4 into the Lively metabolite temazepam. N-desmethyldiazepam and temazepam are equally further more metabolized to oxazepam. Temazepam and oxazepam are mostly eliminated by glucuronidation.Most side effects don't call for any me
副作用最多见于临床试验中的味觉改变或味觉障碍（比如口中含有苦味或金属味）通常这种味觉改变是短暂的，能持续至该药物的半衰期过期。The kinetic analyze on diazepam metabolism in male Wistar rats exposed that substantial metabolizer rats experienced markedly better V(max) and scaled-down K(m)